It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2. A 2013 in vitro study published in the International Journal of Oncology showed that honokiol synergized chemotherapy drugs in multidrug resistant breast cancer.20 A 2011 in vitro study published in PLoS One found that honokiol enhanced the apoptotic effects of the anticancer drug gemcitabine against pancreatic cancer. Extensive research on natural products has shown that bioactive natural compounds target multiple cellular processes and pathways involved in cancer progression. On the preventive side, honokiol helps reduce the cancer- We have investigated the characteristics of the behavioural effects of honokiol by means of an elevated plus-maze test. Dr. Xi-rui Chen of the University of Toronto, Ontario, Canada, and colleagues tested honokiol on squamous cell carcinoma. Based on the above, honokiol may have cell- and dosage-dependent anti-cancer and cytoprotective effects by targeting diverse pathways. . Honokiol DCA can inhibit the growth of human prostate cancer cells in vitro and suppress the androgen receptor (AR) protein level[1]. Honokiol DCA (20-40 M; 24 [53] Honokiol, a natural biphenolic compound, exerts anticancer effects through a variety of mechanisms on multiple types of cancer with relatively low toxicity. The pre Honokiol (HNK) is a small-molecule polyphenol isolated from the bark and seed cones of Magnolia officinalis. Honokiol Dosage. Honokiol is the active principle of magnolia extract. Honokiol was injected intraperitoneally every other day into tumor bearing Balb/c nude mice. Honokiol influences cellular and genetic pathways to halt cancer growth and metastasis, trigger apoptosis, reduce inflammation, reduce free radicals and protect neurological function. In vivo and animal studies have demonstrated honokiol's potential for multiple anticancer actions. 5 Honokiol (HNK) is a small organic molecule purified from magnolia species and has demonstrated anticancer activities in a variety of cancer cell lines; however, its effect on oral squamous cell carcinoma (OSCC) cells is unknown. . Pure HonokiolNature's "Smart Drug" Pure honokiol is a highly active compound extracted from Magnolia officinalis bark. Honokiol is effective on inducing apoptosis in SVR angiosarcoma cells. Prevention: Start with 500 mg 2x/day, and after one month the dosage can be dropped to 500 mg 1x/day, or 250 mg 2x/day. Honokiol (HK) is a natural product isolated from the bark, cones, seeds and leaves of plants belonging to the genus Magnolia. [51] In human gastric cancer cells, treatment with honokiol reduced tumor size by causing programmed cell death. Beyond Cancer With Honokiol. Adenosine 5'phosphateactivated protein kinase (AMPK), an essential regulator of cellular homeostasis, may control cancer progression. Honokiol (HNK) is a bioactive component isolated from the Chinese traditional herb Magnolia officinalis, which has been demonstrated to be a potent anticancer drug with activity in inducing apoptosis and inhibiting the . In human colorectal cancer cell line, honokiol induced programmed cell death in a dose-dependent manner. They also talked of how Honokiol could prevent chemo resistance and increase the life span of drugs. Honokiol (HK) is a polyphenol isolated from the barks, leaves, seeds and cones of plants of Magnolia genus. 1 Introduction. Honokare is a full spectrum 12:1 supercritical extract of honokiol, magnolol and astragaloside containing five organic and wildcrafted roots and barks, with six wildcrafted organic essential oils infused into a humic and fulvic acid solubilized solution to increase . Another anti-cancer drug camptothecin (CPT), isolated from the bark of Camptotheca . Background: We have shown previously that honokiol (HNK), a bioactive component of the medicinal plant Magnolia officinalis, inhibits growth of human prostate cancer cells in vitro and in vivo. Honokiol's in vivo toxicity record thus far shows it to be extremely safe. HNK was well tolerated in multiple animal models when administered orally, intravenously (IV), and via intraperitoneal route. . The honokiol-mediated growth inhibition and apoptosis induction are not restricted to the cultured prostate cancer cells because suppression of PC-3 xenograft growth by honokiol administration, at least at the 2 mg/mouse dose, correlated with increased apoptosis (TUNEL positive apoptotic bodies) and decreased proliferation index (PCNA staining). In this review, we discuss honokiol, a plant bioactive compound that originates mainly from the Magnolia species. Magnolia has been taken safety orally for up to 6 weeks, and as a toothpaste for around 6 months, side effects may include: Tiredness; Headaches; Heartburn . Dosage: Adult - one to two capsules two times daily after meal. In addition, our studies found that honokiol in combination with irradiation can even enhance the sensitivity of colon cancer stem cells (CSCs) to . Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets Pharmacol Res. The types of cell death induced by honokiol were primarily autophagy and apoptosis . Thousands of published studies and extensive clinical use show pure honokiol delivers a remarkable array of powerful therapeutic actions. Scopes and hurdles. Recommended dosage: 150-300 mg for a 150lb person; 200-400 mg for a 200lb person; 300-500 mg for a 250lb person . Effect on tumour: Honokiol has shown pro-apoptotic effects in melanoma, sarcoma, leukaemia, prostate, bladder, lung, and oral squamous cell carcinoma and colon cancer cell lines. To the best of our knowledge, the present study was the first to . In addition, Benefits: To reduce anxiety and enhance sleep Supportive treatment for cancers. It is effective in combating multiple drug resistance (MDR), and works well with other anticancer therapies. HNK has been shown to enhance the effects of chemotherapy and inhibit drug resistance in preclinical models. Honokiol enhances the anticancer effect of oxaliplatin in colon cancer cells [80]. Magnolia Bark (Honokiol) Side effects. However, the effect of HNK on androgen receptor (AR) signaling has not been studied. 2019 Jun; 144:192-209 . Treatment of SVR cells with honokiol causes decreased phosphorylation of MAP kinase, akt, and c-src. Anxiety: 250 mg x 2/day. [52] In a rat model of brain cancer, honokiol injection given twice per week for 3 weeks significantly reduced tumor volume. Honokiol raise the efficacy of anticancer drug imatinib against human leukemia cells [81]; lapatinib against HER-2 over-expressed breast cancer cells [82]; adriamycin (doxorubicin) against 4T1 cells [83]; paclitaxel and doxorubicin against HCC cells [37], among . It is commonly obtained from Magnolia officinalis, a herb commonly used in Chinese medicine.Previous studies demonstrated that HK possess antioxidant properties [], antiinflammatory properties [], antithrombosis and anticancer activities [3, 4], induction of . It possesses anti-cancer activity which can efficiently impede the growth and bring about apoptosis of a diversity of cancer cells. Methods: LNCaP, C4-2, and TRAMP-C1 cells were used for various assays. (10) Below are suggested dosages according to clinical use guidelines: Active cancer: 1 g x 3/day (starting at lower dosage and building up to full dose) Cancer prevention/post cancer therapy: 1 g/day. The results showed that HNK inhibited the growth and proliferation of OSCC cells in vitro in a time and dose . Addition of oleic acid also resulted in better retention of drug in the porcine mammary papilla (965.4180.26 g/cm2) compared with breast skin (294.16 8.49 g/cm2). The mechanism involved . Honokiol is a highly active compound and is often called nature's "smart drug" because of its numerous mechanisms against cancer as well as other conditions. This type of cancer has a response rate of only 30 to 40 percent to most commonly used cytotoxic chemotherapy agents in large studies. At 5-10 microg/mL for 48 h, honokiol induced apoptosis through activating Caspase cascades. PLoS One -Santalol, A Skin Cancer Chemopreventive Agent with Potential to Target Various Pathways Involved in Photocarcinogenesis Honokiol shows pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines. Various studies have proven that honokiol exerts broad-range . Furthermore, our study showed that honokiol can also enhance the sensitivity of colon cancer cells to irradiation, which can safely reduce the dose of radiation without affecting the outcome . The combination was tested against an independent honokiol dose and an independent radiation dose. . Considerations The dosage-dependent effects of honokiol revealed in these in vitro studies may serve as a reference for animal in vivo studies in the future. Honokiol has been demonstrated to enhance the effectiveness of chemotherapy drugs and to inhibit drug resistance through the downregulation of p-glycoprotein in a variety of preclinical models. Both independent doses were not as effective in shrinking the tumor as the combination dose. An in vitro and in vivo study discovered that honokiol inhibits breast cancer cells from growing and could boost the effects of other drugs used against . In vivo studies showed that honokiol dose-dependently suppressed tumor growth of pancreatic cancer in the nude mice and up-regulated miR-101 expression but down-regulated Mcl-1 expression in tumor tissues. . Our results showed that honokiol caused dose-dependent and time-dependent cell death in human osteosarcoma cells. 3. Pharmacokinetics study demonstrated that, honokiol . In addition to its antitumor properties, honokiol is a strong antioxidant. Each bottle of HonoPure contains 120 capsules with 250 mg in each capsule, a total of 30 grams per bottle. Honokiol alone inhibited the growth of human lung cancer A549 in lung carcinoma models, and when combined with cisplatin, enhanced antitumor efficacy by increasing apoptosis and inhibition of angiogenesis.33 Honokiol inhibited several human breast cancer cell lines, as well as drug-resistant breast cancer cell lines. Thus, honokiol is more selective in the receptors it binds to, which enables it to produce a similar anxiolytic effect with fewer detrimental side effects. Fights cancer through multiple mechanisms Synthetic drugs developed as chemotherapeutics have repeatedly shown adverse side effects and development of chemoresistance. Thus, key factors controlling EMT have been identified as potential targets to prevent and treat metastatic cancer [7-9]. Honokiol enhances the anticancer effect of oxaliplatin in colon cancer cells [].Honokiol raise the efficacy of anticancer drug imatinib against human leukemia cells []; lapatinib against HER-2 over-expressed breast cancer cells []; adriamycin (doxorubicin) against 4T1 cells []; paclitaxel and doxorubicin against HCC cells [], among others. Anti-Cancer Effects of Honokiol. Honokiol Enhances Paclitaxel Efficacy in Multi-Drug Resistant Human Cancer Model through the Induction of Apoptosis (2014) Xu Wang et al. Honokare The newest, most effective honokial extract on the market today. In fact, honokiol offers both preventive and active therapeutic benefits. shown to improve radiation treatment and help reduce painful side effects. Anti-cancer effect of honokiol was demonstrated with the decrease in the release of cytokine IL-6 and further suppression of Ki-67 proliferative protein. 5-13 For example, HNK is beneficial with etoposide at inducing apoptosis in human breast cancer cells 7; cisplatin in vivo in ovarian and colon cancer . Honokiol DCA (Honokiol dichloroacetate) is a dichloroacetate analog of Honokiol. Recent studies reported honokiol inhibits cancer metastasis by blocking EMT through modulation of Snail/Slug protein translation or . Cancer is basically a multifactorial disease that necessitates the modulation . Side effects: Results: Our results showed that honokiol induced apoptosis of RKO cells in a time- and dose-dependent manner. Honokiol, magnolol, and parthenolide are the compounds believed to be the active ingredients. In the plus-maze test a single oral dose of 20 mg k Inflammatory conditions: 250-500mg x 2/day. They also confirmed that Honokiol could sensitise cancer cells making chemotherapy and radiotherapy more effective and stated that its use should mean that less chemotherapy drug levels needed to be used when Honokiol was present. Honokiol, a neolignane derivative of Magnolia bark, has central depressant action and, at much lower doses, anxiolytic activity. One particular study found that an active dose as small as 0.2 mg/kg can possibly significantly increase exploratory behavior and decrease anxiety-related behavior in animal models. Honokiol's powerful synergistic abilitiey is a key rea-son why it plays such an important role within integrative cancer protocols.
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